Spinal Cord Interneurons (SC Interneurons)

Spinal cord interneurons are a diverse group of neurons located within the grey matter of the spinal cord. They act as intermediaries between sensory and motor neurons, playing critical roles in integrating sensory information, modulating reflexes, coordinating locomotion, and regulating autonomic functions. These neurons can be classified based on their function (local vs. propriospinal), neurotransmitter type (inhibitory GABAergic/glycinergic vs. excitatory glutamatergic), or genetic lineage (e.g., dI1-dI6, V0-V3 classes). After spinal cord injury, interneuronal circuits exhibit plasticity, offering potential for therapeutic intervention to restore lost function.

Other names

Spinal interneuronal circuitsSpinal interneuronsInterneurons in the spinal cord