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Target intelligence / Profile preview
Spindle apparatus coiled-coil protein 1 (SPDL1)
- Target
- SPDL1
- Molecular classification
- Other (coiled-coil domain-containing protein), Adapter protein (links dynein/dynactin motor complexes)
01
Overview
Spindle apparatus coiled-coil protein 1 (SPDL1, Protein Spindly) is an adapter protein required for accurate chromosome segregation during cell division. It promotes dynein and dynactin localization to kinetochores and regulates spindle orientation and mitotic checkpoint signaling, thereby ensuring proper microtubule attachment and chromosome alignment. Mutations or altered expression of SPDL1 have been implicated in increased risk for idiopathic pulmonary fibrosis and some cancers, highlighting its biological and pathogenic significance. SPDL1 acts mechanistically by recruiting dynein/dynactin motors to kinetochores, facilitating the transition from lateral microtubule interaction to end-on attachment, and influencing cell migration by localizing to the leading edge of motile cells
- Other names
- Protein SpindlyCCDC99hSpindlyFLJ20364Arsenite-related gene 1 proteinCoiled-coil domain-containing protein 99Rhabdomyosarcoma antigen MU-RMS-40.4ASpindle apparatus coiled-coil domain-containing protein 1Spindly homolog (Drosophila)rrhabdomyosarcoma antigen protein MU-RMS-40.4A
02
Mechanism of action
None established for drugs, but hypothetical mechanisms would involve inhibition or modulation of SPDL1’s role in spindle formation or checkpoint regulation
03
Biological functions
Mitotic spindle formationChromosome segregationMicrotubule-kinetochore attachmentMitotic checkpoint regulationCell migration
04
Disease associations
Cancer (implicated in the spread of colorectal and other cancers due to its role in cell migration)Idiopathic pulmonary fibrosis (IPF; genetic variant increases risk)Seckel syndromeLung non-small cell carcinoma
05
Safety considerations
Notable safety or therapeutic concerns have not been formally described, but targeting SPDL1 could theoretically interfere with essential cell division processes and cause toxicity
06
Biomarkers
Missense variant (rs116483731, p.Arg20Gln) is associated with increased risk of idiopathic pulmonary fibrosis and may serve as a genetic biomarker for diagnosis or risk stratification
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