Spindle pole body component 24 homolog (SPC24)

Spindle pole body component 24 homolog (SPC24) is an essential subunit of the highly conserved NDC80 kinetochore complex, which connects centromeres of chromosomes to spindle microtubules during mitosis[1][2][3]. The NDC80 complex is a heterotetramer composed of NDC80, NUF2, SPC24, and SPC25; SPC24, together with SPC25, forms a globular domain that interacts with other centromere proteins to anchor the complex at the kinetochore[1][3]. This complex provides the primary molecular interface for chromosome-microtubule attachment, ensuring accurate chromosome segregation[1][2][3]. SPC24's interactions, especially with centromere proteins such as CENP-T (Cnn1 in yeast), are regulated by phosphorylation and are critical for the structural integrity and function of the kinetochore[3]. Defective SPC24 expression or function can lead to chromosome missegregation and is linked to chromosomal instability seen in cancers, but it is not currently a direct therapeutic or biomarker target[1][2]. Key context: SPC24 is not a classic "receptor" or drug target but is vital for cell proliferation and survival through its role in mitosis. Its disruption, therefore, is likely to be broadly cytotoxic rather than selectively therapeutic.

Other names

Kinetochore protein Spc24SPC24SPBC24hSpc24FLJ90806spindle pole body component 24 homolog

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