Spindlin-1 (SPIN1)

Spindlin-1 is a chromatin reader protein encoded by the SPIN1 gene in humans. It contains three Tudor-like domains that specifically recognize and bind to histone H3 trimethylated at lysine 4 (H3K4me3) and lysine 9 (H3K9me3), integrating into the regulation of chromatin structure and gene transcription[2][4][6]. Spindlin-1 acts as a transcriptional co-activator, promotes expression of rRNA genes, and is implicated in cell cycle control[1][2]. It is highly expressed in certain cancer cells, such as ovarian cancer, and has been identified as a putative oncogene[1][4]. The protein localizes mainly to the nucleolus and at rDNA loci, participating in selective transcriptional activation. Small molecule inhibitors have been developed to target its Tudor domains, representing a potential therapeutic strategy for cancer where SPIN1 is dysregulated[4].

Other names

Spindlin1SPIN1Spin1Meiotic spindle-binding proteinSpin/Ssty gene family protein

Inhibition of chromatin reader function by blocking Tudor domain-mediated recognition of methylated histone marks Modulation of gene transcription via disruption of chromatin effector complexes