Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Spindlin family member 2B pseudogene 1 (SPIN2P1)
- Target
- SPIN2P1
- Molecular classification
- Other (Pseudogene, does not encode a receptor, enzyme, transporter, etc.)
01
Overview
SPIN2P1 (spindlin family member 2B pseudogene 1) is a human pseudogene classified in the spindlin family. It does not encode a functional protein and has no known biological or disease roles. Its high sequence similarity to adjacent protein-coding genes can cause confusion and misclassification in clinical genetic testing, impacting interpretation of disease risk, particularly in cancer genetics. Unlike its protein-coding paralog SPIN2B, SPIN2P1 should not be considered a therapeutic target, and its variants should not be interpreted as pathogenic unless evidence demonstrates a direct functional impact. SPIN2B (spindlin family member 2B), the protein-coding gene, is involved in regulation of cell cycle progression, apoptosis inhibition, and histone modification (H3K4me3 binding); however, these functions do not apply to SPIN2P1. SPIN2P1's status as a pseudogene has led to reclassification of some variants previously associated with disease risk once it was shown that they are located in SPIN2P1, not in the functional gene.
- Other names
- SPIN2 family pseudogene 1SPIN2P1spindlin family member 2B pseudogene 1
02
Safety considerations
Potential for misclassification of genetic variants as pathogenic due to sequence homology with functional genes (such as SPIN2B or PMS2), which can impact cancer risk interpretation and clinical management
Beyond the preview
Go deeper on Spindlin family member 2B pseudogene 1 (SPIN2P1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Spindlin family member 2B pseudogene 1 (SPIN2P1).