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Target intelligence / Profile preview
Spindlin family member 3 (SPIN3)
- Target
- SPIN3
- Molecular classification
- Tudor domain-containing protein, Epigenetic reader protein, Other (chromatin-associated protein)
01
Overview
Spindlin family member 3 (SPIN3) is a human protein belonging to the spindlin/tudor domain family. It possesses a tudor-like domain that enables binding to specific methylated lysine residues on histones, such as H3K4me3, suggesting a potential role in recognizing epigenetic histone modifications[6]. While similar proteins in the family, notably Spindlin-1 (SPIN1), have demonstrated clear roles in transcriptional regulation and oncogenesis through reading histone marks[1], SPIN3’s specific biological function in humans remains poorly understood[3][6]. It is primarily expressed in the nucleus and cytoplasm of various tissues, including the central nervous system[9]. No direct associations with disease, therapeutics, or clinical biomarkers have been reported to date for SPIN3[2][4][6][8].
- Other names
- Spindlin-3SPIN-3TDRD27Spindlin-like protein 3bA445O16.1spindlin-3
02
Mechanism of action
None
03
Biological functions
Potential recognition of histone modifications (specifically H3K4me3)Possible roles in chromatin state and transcriptional regulation (by analogy to SPIN1, but not well characterized for SPIN3)Other
04
Disease associations
Other
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