Spire type actin nucleation factor 2 (SPIRE2)

Spire type actin nucleation factor 2 (SPIRE2) is a cytoskeletal regulator and actin-binding protein characterized by multiple WASP homology 2 (WH2) domains, enabling actin nucleation by organizing actin monomers into a configuration favorable for filament assembly[2][6]. SPIRE2 remains associated with the pointed end of nascent filaments, facilitates intracellular vesicle transport, and is essential for processes such as spindle positioning during meiosis and DNA repair after double-strand breaks[1][5][6]. SPIRE2 coordinates actin assembly with formin-family proteins, participating in the formation of actin tracks at organelle membranes, and is involved in cytoskeletal dynamics across diverse cellular compartments[3][6]. Deficiency in SPIRE2 disrupts essential cytoskeletal processes, impacting events such as oogenesis, actin mesh formation, and chromatin movement during DNA repair[4][5]. While it plays critical biological roles, SPIRE2 is not considered a classical therapeutic target.

Other names

Protein spire homolog 2SPIRE2KIAA1832SPIR2Spir-2spire actin nucleation factor 2spire family actin nucleation factor 2spire homolog 2