Spleen and Stomach

The 'Spleen and Stomach' (Pi-Wei) is a central functional organ system in Traditional Chinese Medicine (TCM) rather than a specific molecular target or receptor. It is traditionally known as the 'root of postnatal life' and is responsible for the transformation and transportation of food essence to produce 'Qi' and 'Blood,' which nourish the entire body [1][5]. In the context of modern drug development, 'Spleen and Stomach' refers to the digestive system and its integrated immune and metabolic functions, often studied in relation to chronic gastritis and gastric cancer [4][8]. While TCM herbal formulas like Huangqi Jianzhong Tang are said to 'tonify' this system, they actually exert effects through a complex network of molecular targets, including AKT1, TNF-alpha, and various nuclear receptors [9][14]. Therefore, this entry is considered incorrect for use as a specific molecular target, as it represents a physiological system or a clinical syndrome category in integrative medicine [3][10].

Other names

Pi-WeiSpleen-Stomach systemMiddle JiaoSpleen-Stomach meridianDigestive system (TCM)

Traditional Chinese Medicine treatments target the Spleen and Stomach system through multi-component herbal formulas that aim to restore 'Qi' balance, improve nutrient absorption, and regulate systemic immune-metabolic networks rather than binding to a single molecular receptor [1][4][12].