Spleen-kidney yang enhancement

Spleen-kidney yang enhancement is a therapeutic strategy in Traditional Chinese Medicine, aimed at restoring physiological functions associated with Spleen and Kidney yang, understood as the sources of metabolic energy and warmth in the body[4][5][6][9]. This pattern is thought to manifest as chronic fatigue, digestive disturbances (diarrhea, poor absorption), edema, metabolic syndrome, immune dysregulation, and kidney dysfunction[1][2][4][5][8][9]. Treatment involves the use of tonic herbal formulations, aiming to improve ATPase activity, digestive enzyme balance, immune function, and energy metabolism. While animal and clinical models examine associated changes in enzyme activities, immune biomarkers, and metabolic parameters, there is no canonical molecular entity or receptor named "spleen-kidney yang" in Western biomedicine[2][4][9].

Other names

Spleen kidney yang deficiency syndromeSpleen and kidney yang deficiencySpleen and kidney yang tonicYang-invigorating therapy

Enhancement of ATPase activities (Na⁺-K⁺-ATPase, Ca²⁺-Mg²⁺-ATPase) in animal models. Modulation of digestive enzymes (amylase, sucrase, lactase). Immune system regulation (macrophage activity, Treg/TGFβ1 modulation, anti-inflammatory actions). Energy metabolism improvement and antioxidation (e.g., glutathione levels).