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Spleen-stomach axis support via multi-herb synergy
01
Overview
The "spleen-stomach axis support via multi-herb synergy" is a term from traditional Chinese medicine (TCM) describing the therapeutic enhancement of gastrointestinal and immune function by combining multiple botanicals. This approach, seen in formulas such as Sijunzi decoction and others, is believed to alleviate syndromes like spleen deficiency by synergistically modulating gut microbiota, promoting immune balance, restoring intestinal barrier integrity, and regulating metabolic signaling pathways. Although multi-omics and pharmacological studies reveal alterations in microbiome composition, cytokine levels, and barrier functions, this axis is not a discrete protein, receptor, or molecular target recognized in contemporary molecular pharmacology[1][2][3][4][7]. This "target" is thus not a specific molecular entity, and the name should not be mapped to a canonical molecular target or abbreviation.
- Other names
- Spleen-stomach axisSpleen-stomach function supportSpleen deficiency supportSpleen-stomach synergy
02
Mechanism of action
Multi-herb synergy to regulate microbiota–gut–metabolites axis Restoration of gut microbiota composition Modulation of cytokine production and immunological markers Enhancement of gastrointestinal barrier integrity
03
Biological functions
Modulation of gastrointestinal functionImmune regulationRegulation of gut microbiome and intestinal barrier functionAnti-inflammatory effects
04
Disease associations
Gastrointestinal disorders (e.g., functional gastrointestinal disorders, spleen deficiency syndrome)Chronic diarrheaImmune dysfunction
05
Safety considerations
Lack of target specificityHerb–drug interactionsVariability in herbal preparation and dosingLimited mechanistic understanding by modern standards
06
Biomarkers
Changes in gut microbiome composition (e.g., increased beneficial bacteria such as Lactobacillus species)Levels of gastrointestinal hormones and neurotransmittersCytokine profiles (e.g., TNF-α, IL-6, IL-10)
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