Target intelligence / Profile preview

Spleen-stomach yang deficiency syndrome

01

Overview

Spleen-stomach yang deficiency syndrome is a diagnostic pattern in Traditional Chinese Medicine (TCM), referring to insufficient "yang" (warming and energizing function) of the spleen and stomach, resulting in coldness and hypoactivity in digestive and metabolic functions. Main symptoms include abdominal pain, poor appetite, loose stools or diarrhea, a pale tongue with white coating, fatigue, cold limbs, and a weak pulse. In TCM, the spleen and stomach jointly manage transformation and transportation of nutrients; their yang deficiency is linked to 'internal cold,' dampness, and systemic sluggishness. This syndrome does not correspond to a single molecular or protein-based target recognized in modern pharmacology or molecular medicine. This entry cannot be reliably mapped to any gene, receptor, enzyme, transporter, or other canonical biomedical target. It represents a clinical pattern from traditional medical theory, not a discrete molecular entity or protein target.

Other names
Spleen-yang deficiency syndromeSpleen and stomach deficiency syndromeSYDS
02

Mechanism of action

Not applicable (formulas are prescribed based on theoretical restoration of "yang" and digestion; not molecular targeting)

03

Disease associations

various digestive disorderschronic gastritishypothyroidismchronic fatiguesystem-wide energy deficiency
04

Safety considerations

Safety concerns are related to the treatments prescribed for the syndrome, such as potential herb-drug interactions or adverse effects from herbal or pharmaceutical interventions.
05

Interacting drugs

Huangqi Jianzhong Decoction

3 more in the full profile.

06

Biomarkers

pale tongue with white coatingslow/deep/weak pulse

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