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Spliceosome-associated factor SYF2
- Molecular classification
- RNA splicing factor, Spliceosome component
01
Overview
SYF2 is a nuclear protein involved in pre-mRNA splicing as a component of the spliceosome. It plays roles in cell cycle regulation, DNA repair, and is implicated in cancer and neurodegenerative diseases such as ALS. As such it is a potential therapeutic target.
- Other names
- pre-mRNA-splicing factor SYF2
02
Mechanism of action
Inhibition of SYF2 function to disrupt splicing, cell cycle progression, and DNA repair
03
Biological functions
Pre-mRNA splicingCell cycle regulationDNA damage repairRegulation of alternative splicingPromotion of cell proliferation
04
Disease associations
CancerNeurodegenerative diseaseAmyotrophic Lateral Sclerosis (ALS)
05
Safety considerations
Potential for developmental toxicity due to essential role in embryogenesisOff-target effects on other splicing factors
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