Spliceosome-associated protein CWC27 homolog (CWC27)

Spliceosome-associated protein CWC27 homolog (CWC27) is a nuclear protein involved as a component of the spliceosome, particularly the activated (B^act) complex, critical for pre-mRNA splicing[1][2][3][5]. CWC27 interacts with CWC22 to create a molecular platform that recruits the exon junction complex (EJC) core member eIF4A3, orchestrating later splicing events[2][3]. While CWC27 belongs to the cyclophilin peptidyl-prolyl cis-trans isomerase family, it is predicted to lack catalytic activity but retains proline-binding capacity, suggesting a scaffolding role for spliceosome assembly rather than enzymatic activity[1][2][3][5]. Loss-of-function mutations, especially in the C-terminal region, cause autosomal recessive retinal degeneration in humans and mice, often alongside other developmental anomalies[1][3][5]. In cancer (notably bladder), increased CWC27 expression correlates with enhanced proliferation and reduced apoptosis[1]. There are currently no known small-molecule drugs directly targeting CWC27, and its primary relevance is as a core component of gene expression regulation and a disease-associated gene rather than a classic therapeutic target[1][2][3][5].

Other names

SDCCAG10NY-CO-10Serologically defined colon cancer antigen 10RPSKASpliceosome-associated protein CWC27 homologPPIase CWC27PPIase SDCCAG10Antigen NY-CO-10Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog