Target intelligence / Profile preview

Splicing factor 1 (SF1)

Target: SF1
Molecular classification: Other (RNA-binding protein), Transcription factor

Overview

Splicing factor 1 is an RNA-binding protein essential for the early steps of spliceosome assembly, specifically recognizing the branch point sequence in pre-mRNA introns and facilitating the ATP-dependent assembly of the spliceosomal complex. It also plays roles in nuclear retention of pre-mRNA and may act as a transcriptional repressor. Mutations and altered expression of SF1 have been linked to certain cancers and endocrine neoplasias.

Other names: Zinc finger protein 162ZFM1ZNF162BBPmBBPZCCHC25Branch point-binding proteinD11S636Mammalian branch point-binding proteinTranscription factor ZFM1Zinc finger gene in MEN1 locus

Biological functions

Pre-mRNA splicing (recognition of the intron branch point sequence)Spliceosome assemblyTranscriptional repressionNuclear retention of pre-mRNA

Disease associations

CancerMultiple endocrine neoplasia type IOther

Beyond the preview

Go deeper on Splicing factor 1 (SF1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Splicing factor 1 (SF1).

Explore the full profile