Splicing factor 3a subunit 2 pseudogene

The ENSG00000270578 locus corresponds to a pseudogene related to the gene encoding splicing factor 3a subunit 2, 66kDa. Pseudogenes are regions of DNA that resemble functional genes but are generally noncoding due to mutations or absence of regulatory elements. There is no evidence that this pseudogene is transcribed, translated, or involved in disease or therapeutic targeting. The functional splicing factor 3a protein participates in formation and activity of the spliceosome, a complex necessary for pre-mRNA splicing, but the pseudogene does not contribute to this activity. The active splicing factor 3a protein (SF3A2 or SF3A3) is essential for spliceosome assembly, but "subunit 2 pseudogene" is not functionally implicated in these processes. The terminology is potentially confusing—ensure you distinguish the pseudogene (ENSG00000270578) from the functional protein-coding gene (which might be SF3A2 or SF3A3, but neither is this locus).

Other names

ENSG00000270578Splicing factor 3a, subunit 2, 66kDa, pseudogene