Splicing factor 3A subunit 3 (SF3A3)

Splicing factor 3A subunit 3 (SF3A3) is a protein crucial for pre-mRNA splicing, functioning as the third subunit of the SF3A heterotrimeric complex within the U2 small nuclear ribonucleoprotein (snRNP) particle of the spliceosome. It is essential for the conversion of 15S U2 snRNP into the active 17S U2 snRNP, facilitating branch-point recognition and early spliceosome assembly. It contains a zinc finger domain required for interactions within the complex and binds RNA directly. SF3A3 has multiple transcript variants and is involved in additional cellular processes including RNA stabilization, degradation, and possibly direct chromatin interactions. Dysregulation of SF3A3 has been associated with cancer pathogenesis, especially as a modulator of metabolic pathways and cancer stem-like cell phenotypes in contexts such as MYC-driven breast cancer[1][2][3][5][6][7].

Other names

PRP9PRPF9SAP61SF3a60Spliceosome-associated protein 61