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Target intelligence / Profile preview
Splicing Factor 3B Subunit 1 (SF3B1)
- Target
- SF3B1
- Molecular classification
- Splicing factor, Spliceosome component, HEAT repeat protein
01
Overview
Splicing factor 3B subunit 1 (SF3B1) is a core component of the spliceosome, specifically part of the splicing factor 3b protein complex. It plays a critical role in pre-mRNA splicing, which is essential for generating mature messenger RNA from precursor transcripts. Mutations in SF3B1 are recurrently observed in several cancers, including myelodysplastic syndromes, chronic lymphocytic leukemia, and breast cancer. It is also involved in ferroptosis resistance. SF3B1 is therefore a therapeutic target in cancer.
- Other names
- Hsh155MDSPRP10PRPF10SAP155SF3b155
02
Mechanism of action
SF3B1 inhibitors are being developed to disrupt splicing in cancer cells, leading to cell death. Specific mechanisms depend on the inhibitor.
03
Biological functions
Pre-mRNA splicingIntron branch site recognitionU2 snRNP assemblymRNA processing
04
Disease associations
CancerChronic Lymphocytic Leukemia (CLL)Myelodysplastic Syndromes (MDS)Breast CancerOrbital Melanoma
05
Safety considerations
Potential for off-target effects due to the ubiquitous nature of splicingDevelopment of resistanceImpact on normal cellular processes
06
Biomarkers
SF3B1 mutations as diagnostic marker for MDS-RS/MDS-RS-TSF3B1 expression levelsSLC7A11 expression
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