Splicing factor 4 pseudogene (SF4 pseudogene)

The **splicing factor 4 pseudogene** (ENSG00000250405) is a human genomic region annotated as a pseudogene, i.e. a segment similar in sequence to the gene encoding splicing factor 4 (SF4) but does not encode a functional protein[1][5]. Pseudogenes typically arise from gene duplication or retrotransposition events but have lost protein-coding function due to mutations and/or absence of proper regulatory elements. The SF4 pseudogene shares sequence homology with the functional splicing factor 4 gene, a member of the SR protein family that regulates pre-mRNA splicing, but is not expressed nor translated into a functional product. As such, it does not participate in spliceosome function, does not contribute to splicing regulation, and is not considered a therapeutic target nor a disease gene. It is commonly referenced for genomic annotation but bears no known biological or clinical relevance. \n\n**Additional Context:**\n- Pseudogenes like this one are widespread in the human genome and may occasionally regulate expression of their parent genes via non-coding RNA mechanisms, but no evidence supports such a regulatory role for the splicing factor 4 pseudogene[1][5].\n- The functional analog, **splicing factor 4 (SF4 or SRSF4)**, is a member of the serine/arginine-rich family of splicing factors, involved in pre-mRNA splicing and implicated in various diseases[3][4], but ENSG00000250405 itself does not encode this protein.\n- The presence of \"pseudogene\" in the name and genome annotation reliably indicates it is not a therapeutic target.\n\n**Summary:** \nENSG00000250405 (splicing factor 4 pseudogene, LOC402229) is a non-functional, non-coding pseudogene and not a valid therapeutic target. Any references to drug interactions, functional mechanisms, or clinical utility should refer to the actual SF4 protein or gene (SRSF4), not this pseudogene[1][5].

Other names

Splicing factor 4 pseudogeneLOC402229SF4 pseudogeneENSG00000250405