Splicing factor proline- and glutamine-rich (SFPQ)

Splicing factor proline- and glutamine-rich (SFPQ) is a multifunctional nuclear RNA- and DNA-binding protein involved in alternative splicing, transcriptional regulation, RNA transport, DNA repair, and apoptosis. SFPQ is a member of the DBHS protein family and forms complexes with partners such as NONO/p54^nrb^ and PSPC1. It regulates vital cellular processes, including the control of pro- and antiapoptotic isoforms of caspases through modulation of alternative splicing factors (notably SRSF2). SFPQ is essential for cell viability; its upregulation is linked to platinum-chemoresistance in ovarian cancer and viral mRNA processing, and it interacts with several proteins including PTBP1 and NONO. Inhibition or knockdown of SFPQ leads to apoptosis and enhanced sensitivity to DNA-damaging agents.

Other names

PSFPTB-associated splicing factorhPOMp100PPP1R140100 kDa DNA-pairing proteinDNA-binding p52/p100 complexPolypyrimidine tract-binding protein-associated splicing factorprotein phosphatase 1 regulatory subunit 140POMP100epididymis secretory sperm binding proteinSFPQ/PSF

Drugs (cisplatin, carboplatin): induce DNA damage and apoptosis; SFPQ overexpression mediates resistance by promoting antiapoptotic transcripts via splicing regulation. Caspase inhibitors: block caspase activation downstream of SFPQ knockdown, rescuing cell viability.