Splicing factor U2AF 35 kDa subunit (U2AF1)

U2AF1 is a splicing factor of 35 kDa that serves as the small subunit of the U2 auxiliary factor complex. It is essential for the recognition of the AG dinucleotide at the 3’ splice site during spliceosome assembly in pre-mRNA processing. Mutations in U2AF1, including the Q157R substitution, are recurrent in multiple hematologic malignancies and solid tumors, and have been shown to alter normal splicing patterns, contributing to oncogenesis and disease progression. The U2AF1 protein acts primarily through RNA-protein and protein-protein interactions that facilitate gene expression regulation. U2AF1 is a promising but challenging therapeutic target due to its ubiquitous role in normal cell physiology[1][3][9].

Other names

U2 small nuclear RNA auxiliary factor 1Splicing factor U2AF 35 kDa subunitU2AF1

Drugs targeting spliceosome machinery can act by modulating splicing efficiency or correcting aberrant splicing induced by U2AF1 mutations.