Splicing regulator SDE2 (SDE2)

Splicing regulator SDE2 (SDE2) is a ubiquitin-fold-containing RNA binding protein that functions as a splicing regulator in the spliceosome machinery[1][2][3][4]. In both human and fission yeast, SDE2 is synthetized as an inactive precursor that is processed by ubiquitin-specific proteases to generate an active C-terminal fragment (SDE2-C), which becomes incorporated into the spliceosome[1][2][3]. SDE2 selectively regulates splicing of specific subsets of pre-mRNAs in an intron-specific manner, rather than being required for global pre-mRNA splicing[2][3]. Loss or defective activation of SDE2 leads to inefficient removal of selected introns, altered telomeric silencing, compromised DNA replication, and defects in genomic stability[2][3]. SDE2 also plays a role in ribosome biogenesis and acts as an adaptor protein for various RNA processes[4]. While it is associated with processes relevant for cancer and genomic integrity, there are currently no drugs reported to specifically target SDE2, nor is it a recognized therapeutic target[2][3][4].

Other names

C1orf55FLJ35382Replication stress response regulator SDE2dJ671D7.1SDE2 telomere maintenance homologUPF0667 protein C1orf55protein SDE2 homolog