Target intelligence / Profile preview

Squalene Monooxygenase (SQLE)

Target: SQLE
Molecular classification: Enzyme, Monooxygenase, Flavoprotein

Overview

Squalene monooxygenase (SM), also known as squalene epoxidase or SQLE, is a key enzyme in the cholesterol biosynthesis pathway. It catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, representing a rate-limiting step in sterol and steroid biosynthesis. This reaction is essential for the production of cholesterol and other sterols in eukaryotic cells. SM is a therapeutic target for hypercholesterolemia, cancer, and fungal infections. The enzyme is regulated by cholesterol levels and squalene.

Other names: Squalene Epoxidase

Mechanism of action

Inhibition of squalene monooxygenase, leading to decreased sterol synthesis.

Biological functions

Sterol biosynthesisCholesterol synthesisEpoxidation

Disease associations

HypercholesterolemiaCancerFungal infections

Safety considerations

Potential for off-target effects due to structural similarities with other monooxygenases.Development of resistance in fungal infections.

Interacting drugs

Terbinafine

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