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Squalene Monooxygenase (Yeast)

Molecular classification: Enzyme, Flavoprotein monooxygenase

Overview

Squalene monooxygenase, encoded by the ERG1 gene in *Saccharomyces cerevisiae*, catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, a key step in ergosterol biosynthesis. It is a flavoprotein monooxygenase containing FAD and utilizes NADPH and molecular oxygen for activity. Located primarily in the endoplasmic reticulum, this enzyme is a validated target for antifungal drugs like terbinafine. Inhibition disrupts cell membrane integrity in fungi.

Other names: Squalene EpoxidaseERG1 proteinErg1p

Mechanism of action

Inhibition of squalene monooxygenase leading to ergosterol depletion and accumulation of toxic squalene

Biological functions

Ergosterol biosynthesisSterol biosynthesisEpoxidation

Disease associations

Infection

Interacting drugs

Terbinafine

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