SR-related CTD-associated factor 11 (SCAF11)

SR-related CTD-associated factor 11 (SCAF11) is an RNA-binding protein critically involved in pre-mRNA alternative splicing by regulating spliceosome assembly. It localizes to the nuclear body and nucleolus, reflecting its central role in nuclear RNA maturation. SCAF11 is associated with multiple aliases due to its interactions with various splicing factors, including SC35 and SRSF2, and has been identified as a renal carcinoma antigen and as an autoantigen in immune-mediated diseases. Its biological importance stems from its influence on gene expression and cellular processes such as cell fate determination, development, and immune response regulation, though it is not a canonical therapeutic target like an enzyme or receptor. Notes: - Despite the alias "CASP11," SCAF11 in humans is not the same as murine Caspase-11 or human Caspase-4/5, which are inflammatory caspases and established drug targets in immune-mediated diseases. - SCAF11 is not a druggable therapeutic target but is biologically significant in splicing regulation and disease contexts like cancer and autoimmunity. - If used in drug screens or biomarker assays, the “Renal carcinoma antigen NY-REN-40” alias may be specifically relevant.

Other names

CASP11SFRS2IPSIP1SRRP129SRSF2IPSplicing factor, arginine/serine-rich 2-interacting proteinSerine/arginine-rich splicing factor 2-interacting proteinSplicing regulatory protein 129CTD-associated SR protein 11SC35-interacting protein 1SRSF2-interacting proteinRenal carcinoma antigen NY-REN-40SFRS2-interacting proteinSRrp129

Not applicable; no therapeutic drugs directly target SCAF11. Mechanistic role is regulation of spliceosome assembly and pre-mRNA splicing. May intersect with pathways controlled by other proteins (e.g., caspases and inflammatory mediators).