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Target intelligence / Profile preview
Src-associated in mitosis 68 kDa protein (Sam68)
- Target
- Sam68
- Molecular classification
- STAR family, RNA-binding protein, Signal Transducer, Adaptor protein
01
Overview
Sam68 (Src-associated in mitosis, 68 kDa protein), encoded by the KHDRBS1 gene, is a member of the STAR family of RNA-binding proteins. It primarily functions as an adaptor molecule involved in regulating alternative splicing, signal transduction, and cell cycle progression. Post-translational modifications, such as tyrosine phosphorylation, acetylation, and arginine methylation, regulate its activity. Sam68 is implicated in cancer cell proliferation/survival and plays a role in HIV replication.
- Other names
- KHDRBS1KH domain containing, RNA binding, signal transduction associated 1
02
Mechanism of action
Modulates pre-mRNA splicing, interacts with signaling proteins, and facilitates CRM1-mediated nuclear export
03
Biological functions
Regulation of alternative splicingSignal transductionCell cycle regulationRNA metabolism
04
Disease associations
CancerHIV infection
05
Safety considerations
Overexpression or dysregulation implicated in cancer cell proliferation/survival
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