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Target intelligence / Profile preview
Src associated in mitosis of 68 kDa (Sam68)
- Target
- Sam68
- Molecular classification
- RNA-binding protein, STAR family protein, Scaffold protein, Transcription factor
01
Overview
Src associated in mitosis of 68 kDa (Sam68), also known as KHDRBS1, is a multifunctional RNA-binding protein involved in gene expression regulation. It acts as a scaffold for signaling complexes and influences mRNA processing, splicing, export, and translation. Sam68's activity is regulated by post-translational modifications, including tyrosine phosphorylation, arginine methylation, acetylation, and sumoylation. It plays a significant role in cancer biology, particularly in prostate and breast carcinomas.
- Other names
- KHDRBS1
02
Mechanism of action
Modulation of RNA processing, splicing, and translation; alteration of transcriptional activity; disruption of protein-protein interactions within signaling complexes.
03
Biological functions
RNA bindingmRNA processingAlternative splicingmRNA exportTranslation regulationSignal transductionTranscriptional regulationScaffolding
04
Disease associations
Cancer
05
Safety considerations
Aberrant splicing events leading to oncogenesisPotential for off-target effects due to widespread RNA binding
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