Src family kinase (SFK) (SFK)

The Src family kinases (SFKs) are a group of non-receptor tyrosine kinases that serve as critical mediators in various intracellular signaling pathways. This family consists of nine members: Src, Yes, Fyn, Fgr, Lck, Hck, Blk, Lyn, and Frk, which are involved in regulating cell growth, survival, adhesion, and migration (PMID: 15181464). SFKs typically interact with cell surface receptors, such as receptor tyrosine kinases and integrins, to relay signals to downstream effectors like STAT3 and PI3K/Akt (PMID: 21663870). In many human cancers, SFKs are frequently overexpressed or hyperactivated, contributing to tumor progression, epithelial-to-mesenchymal transition, and metastasis (Source: National Cancer Institute). Because of their central role in oncogenic signaling and immune cell modulation, SFKs are significant therapeutic targets for small-molecule inhibitors like dasatinib and bosutinib, which are used to treat chronic myeloid leukemia and are being investigated for solid tumors (Source: FDA, PMID: 24511121). The designation "SRC family/other kinases" is often used in pharmacological databases to categorize multi-targeted inhibitors or assays where specific kinase selectivity within or beyond the SFK family is not uniquely defined (Source: ChEMBL).

Other names

SFKsSrc familyNon-receptor tyrosine kinasesProto-oncogene tyrosine-protein kinases

ATP-competitive inhibition of the tyrosine kinase catalytic domain