Src family kinase and Abelson kinase (SFK and ABL)

Src family kinases and Abelson kinase (ABL) are non-receptor tyrosine kinases involved in key pathways regulating cellular proliferation, survival, migration, and cytoskeletal dynamics[1][2]. The Src family includes multiple homologous kinases (c-Src, Fyn, Lck, etc.) sharing a similar domain structure and regulatory mechanism[2]. Abelson kinase (c-Abl or ABL1) shares structural similarity with Src kinases, including SH3, SH2, and kinase domains, and additional unique regulatory regions[1]. Both SFK and ABL play vital roles in physiological signal transduction and are deregulated in various diseases, particularly cancers such as leukemia (for ABL fusion Bcr-Abl) and solid tumors (for SFK)[1][2]. Numerous drugs (notably tyrosine kinase inhibitors like imatinib) have been developed to therapeutically target these enzymes.

Other names

Src family kinase: "c-Src"Src kinaseindividual members such as "Fyn""Lck""Yes""Lyn""Hck""Blk""Fgr""Yrk"Abelson kinase: "c-Abl""ABL1""Abelson tyrosine-protein kinase 1""Bcr-Abl" (fusion)

Inhibition of tyrosine kinase activity; Blockade of ATP binding site; Disruption of downstream signal transduction pathways controlling proliferation and survival