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Src Family Kinase Member SRC (SRC)
- Target
- SRC
- Molecular classification
- Enzyme, Protein Tyrosine Kinase, Non-receptor tyrosine kinase, Src family kinase (SFK)
01
Overview
Src is a non-receptor protein tyrosine kinase and the founding member of the Src family kinases (SFKs). It plays a key role in regulating various cellular processes, including proliferation, differentiation, migration, adhesion, survival, and angiogenesis. Src activity is regulated by phosphorylation and dephosphorylation at key tyrosine residues. Deregulation or constitutive activation of Src has been implicated in oncogenic transformation and cancer progression, as well as other diseases involving fibrosis and immune cell signaling. Inhibiting SFK activity is an active area for anti-cancer drug development.
- Other names
- c-SrcProto-oncogene tyrosine-protein kinase Src
02
Mechanism of action
Inhibition of Src kinase activity through ATP-competitive or allosteric mechanisms.
03
Biological functions
Signal transductionCell proliferationCell differentiationCell migrationCell adhesionCell survivalAngiogenesis
04
Disease associations
CancerOncogenesisFibrosisIdiopathic pulmonary fibrosisChronic kidney disease
05
Safety considerations
Potential for off-target effects due to homology within the SFK family.Development of resistance to inhibitors.Toxicities associated with broad kinase inhibition.
06
Interacting drugs
SFK inhibitors
07
Biomarkers
Src overexpressionSrc phosphorylation status
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