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Src family tyrosine-protein kinase
- Molecular classification
- Enzyme, Protein tyrosine kinase, Non-receptor protein tyrosine kinase
01
Overview
Src family tyrosine-protein kinases (SFKs) are a group of non-receptor protein tyrosine kinases that play crucial roles in regulating cellular processes such as cell morphology, motility, proliferation, survival, gene transcription, immune response, cell adhesion, and cytoskeletal organization. The family includes several members—most notably Src itself (the proto-oncogene c-Src), Yes, Fyn, Fgr (forming the SrcA subfamily), and Lck, Hck, Blk among others. SFK activity is tightly regulated by phosphorylation at specific tyrosine residues within the activation loop and the C-terminal tail.
- Other names
- SFKc-SrcYesFynFgrLckHckBlk
02
Mechanism of action
Kinase inhibition
03
Biological functions
Signal transductionCell growthCell differentiationCell migrationCytoskeletal dynamicsGene expressionImmune responseCell adhesionCell survival
04
Disease associations
CancerIschemiaMyeloproliferative neoplasm
05
Safety considerations
Functional redundancy complicates precise attribution of therapeutic effects.Constitutive activation can have severe developmental consequences.
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