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Target intelligence / Profile preview
Src Homology-2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP2)
- Target
- SHP2
- Molecular classification
- Enzyme, Protein Tyrosine Phosphatase
01
Overview
SHP2 is a non-receptor protein tyrosine phosphatase encoded by the PTPN11 gene. It is ubiquitously expressed and plays a central role in cell signaling downstream of RTKs and cytokine receptors. SHP2 regulates key cellular processes such as growth, proliferation, differentiation, survival, and migration through its modulation of pathways like RAS/MAPK, PI3K/AKT, and JAK/STAT. Mutations in PTPN11 are implicated in Noonan Syndrome, LEOPARD Syndrome, and various cancers. It is considered an attractive drug target for cancer therapy.
- Other names
- Protein Tyrosine Phosphatase Non-Receptor Type 11SypPTP1DSrc homology region 1-containing phosphatase 1PTPN11
02
Mechanism of action
Inhibition of SHP2 phosphatase activity
03
Biological functions
Signal transductionCell growthCell proliferationCell differentiationCell survivalRegulation of apoptosis
04
Disease associations
Noonan SyndromeLEOPARD SyndromeCancerMetachondromatosisHematopoietic malignancies
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