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Target intelligence / Profile preview
Src Homology Region 2-Containing Protein Tyrosine Phosphatase (SHP-2)
- Target
- SHP-2
- Molecular classification
- Enzyme, Protein Tyrosine Phosphatase
01
Overview
SHP-2 is a cytoplasmic protein tyrosine phosphatase that plays a critical role in multiple cellular signaling pathways. It regulates cell growth, differentiation, survival, and immune responses by dephosphorylating specific substrates involved in signal transduction cascades. Mutations in SHP-2 are implicated in several human diseases, including Noonan syndrome, LEOPARD syndrome, and juvenile myelomonocytic leukemia.
- Other names
- PTPN11SypPTP1DShp-ptp2
02
Mechanism of action
Dephosphorylation of target proteins after recruitment via pY-binding through its two SH2 domains, modulating downstream signaling cascades.
03
Biological functions
Cell growthCell differentiationCell survivalImmune regulationSignal transduction
04
Disease associations
Noonan syndromeLEOPARD syndromeJuvenile myelomonocytic leukemiaCancer
05
Safety considerations
Constitutive activation due to mutations leading to disease.
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