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SRC proto-oncogene non-receptor tyrosine kinase
- Molecular classification
- Enzyme, Protein kinase, Non-receptor tyrosine kinase, Src family kinase
01
Overview
SRC (proto-oncogene, non-receptor tyrosine kinase) encodes c-Src, a non-receptor tyrosine kinase belonging to the Src family kinases (SFKs). SRC plays a crucial role in cellular signaling pathways regulating proliferation, differentiation, survival, migration, angiogenesis, and cell adhesion. It acts as a signal transducer downstream of multiple receptors and is implicated in various cancers and other diseases. Activation or overexpression of c-Src has been observed in multiple tumor types. Therapeutic targeting of SRC with small molecule inhibitors is under investigation.
- Other names
- c-Srcpp60c-srcTyrosine kinase pp60(src)Src tyrosine kinasePp60(src)P60-SrcC-src TKC-Src
02
Mechanism of action
SRC phosphorylates specific tyrosines on target proteins, modulating downstream signaling pathways involved in cell survival, proliferation, angiogenesis, invasion, and migration.
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalCell migrationAngiogenesisCell adhesionGene transcriptionCell cycle progressionApoptosis regulationImmune response
04
Disease associations
CancerBreast cancerColorectal cancerMyeloproliferative neoplasmIschemiaInflammation
05
Safety considerations
Functional redundancy among SFKs may limit the efficacy of SRC inhibitors.Overexpression or increased activity due to upstream signals or loss of negative regulation appears more important than direct mutation, which challenges direct mutational targeting.
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