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SRD5A3 antisense RNA 1 (SRD5A3-AS1)
- Target
- SRD5A3-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Non-protein coding RNA
01
Overview
SRD5A3 antisense RNA 1 (SRD5A3-AS1) is a long non-coding RNA gene located on chromosome 4q12, transcribed from the opposite strand of the protein-coding SRD5A3 locus[3][6][7]. As a lncRNA, SRD5A3-AS1 is not translated into protein; instead, it may regulate gene expression by mechanisms common to antisense RNAs, such as RNA interference, chromatin modification, or competition with mRNA transcripts[6]. SRD5A3-AS1 is being investigated primarily for its roles in cancer biology, particularly for its putative involvement in the regulation of cell proliferation and differentiation, but definitive mechanistic and clinical data are still limited[6][7]. No drugs are known to directly interact with SRD5A3-AS1, consistent with the current understanding of lncRNA biology[6][7].
- Other names
- SRD5A3 antisense RNA 1 (non-protein coding)SRD5A3-AS1
02
Biological functions
Regulation of cell proliferationRegulation of differentiationRegulation of apoptosis and migration reported in similar antisense RNAs, but specific mechanistic studies for SRD5A3-AS1 are limited
03
Disease associations
Cancer (lncRNAs including SRD5A3-AS1 have been implicated in various types, though detailed disease role for SRD5A3-AS1 is still emerging)Other (lncRNA dysregulation is broadly linked to several disease states, but direct evidence for SRD5A3-AS1 in non-cancer diseases remains unclear)
04
Biomarkers
Potential biomarker in cancer, especially as changes in SRD5A3-AS1 expression or function might correlate with disease state or prognosis, but specific clinical utility is undetermined
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