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Target intelligence / Profile preview
SREBF pathway regulator in Golgi 1 (SPRING1)
- Target
- SPRING1
- Molecular classification
- Other, Regulatory protein associated with the Golgi apparatus
01
Overview
SREBF pathway regulator in Golgi 1 (SPRING1) is a protein-coding gene that encodes a regulatory protein primarily localized in the Golgi membrane[5][2]. SPRING1 is involved in the positive regulation of the SREBP (Sterol Regulatory Element Binding Protein) signaling pathway, an essential pathway for lipid homeostasis[8][2]. SPRING1 facilitates this process by modulating the correct localization of SCAP, a key component necessary for SREBP activation, from the endoplasmic reticulum to the Golgi apparatus[8]. While critical for lipid metabolism regulation, SPRING1 is not a direct therapeutic target and is not classified as a receptor, enzyme, transporter, or similar druggable class[8][2]. There is no current evidence for its direct involvement in diseases, interaction with drugs, or use as a clinical biomarker.
- Other names
- SREBP regulating gene proteinC12orf49SPRINGFLJ21415POST1LUR1partner of site-1 proteaseUPF0454 protein C12orf49
02
Biological functions
Positive regulation of SREBP signaling pathwayProtein bindingModulation of SCAP (SREBP cleavage-activating protein) localization
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