SRY-box transcription factor 1 (SOX1)

SOX1 encodes a transcription factor with a high mobility group (HMG) DNA-binding domain integral for neurogenesis and embryonic development[1][3][4][5]. SOX1 is one of the earliest neural markers, orchestrating progenitor maintenance and cell fate decisions by keeping neural stem cells undifferentiated, counteracting proneural factors, and regulating lineage-specific genes such as gamma-crystallins in the eye and Hes1 in neurons[1][5]. Its function is tightly regulated through sophisticated post-translational modifications (acetylation, phosphorylation, sumoylation) that fine-tune DNA binding and protein interactions[2]. Dysregulation or altered expression of SOX1, including silencing via methylation, is linked to tumor progression and resistance to chemotherapy[5]. In oncology, SOX1 can function as both a tumor suppressor and a supporter of cancer stem cell maintenance, depending on context[5]. Although not directly targeted by drugs, its pathway and gene expression are under intense investigation for biomarker and therapeutic purposes[5].

Other names

Transcription factor SOX-1SRY-related HMG-box gene 1SRY (sex determining region Y)-box 1SOX1

Not applicable for drugs (no direct antagonists/agonists). SOX1 protein modulates transcriptional activity and is regulated by post-translational modifications