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Target intelligence / Profile preview
SRY-box transcription factor 2 (SOX2)
- Target
- SOX2
- Molecular classification
- Transcription factor, SOX family
01
Overview
SRY-box transcription factor 2 (SOX2) is a nuclear transcription factor that plays a critical role in stem cell biology and mammalian development. It is essential for maintaining the self-renewal and pluripotency of undifferentiated embryonic stem cells, as well as the maintenance of neural stem cells. SOX2 belongs to the SOX (SRY-related HMG-box) family of transcription factors, which are characterized by a highly conserved DNA-binding domain known as the HMG (High-Mobility Group) box.
02
Mechanism of action
SOX2 inhibitors (experimental)
03
Biological functions
Maintenance of embryonic and neural stem cell populationsEarly embryonic developmentNeurogenesisRegulation of gene expression
04
Disease associations
Microphthalmia syndromic 3Septo-optic dysplasiaCancer
05
Safety considerations
Overexpression or underexpression can disrupt normal differentiation processesPotential for off-target effects in regenerative medicine applicationsInhibition may disrupt normal stem cell function
06
Biomarkers
SOX2 expression level in tumors
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