SRY-box transcription factor 8 (SOX8)

SRY-box transcription factor 8 (SOX8) is a member of the SOX (SRY-related HMG-box) family of transcription factors, which are key regulators of embryonic development and cell fate determinations[4][5][6][7]. SOX8 functions by binding to DNA and influencing the transcription of genes involved in neurodevelopment, oligodendrocyte differentiation, and myelination within the central nervous system, as well as in limb and facial morphogenesis. It acts primarily as a transcriptional activator in complex with partner proteins. SOX8 is expressed in various tissues but is especially important in oligodendrocyte maturation and myelin maintenance; its deficiency has been associated with delayed remyelination and developmental deficits, and SNPs near SOX8 have been implicated in multiple sclerosis risk[1][3]. Abnormal SOX8 expression or loss-of-function is linked to male infertility, neurodevelopmental syndromes (such as ATR-16), and certain cancers, most strongly hepatocellular carcinoma, where it may enhance tumor cell proliferation[4][5].

Other names

Transcription factor SOX-8SOX8SRY (sex determining region Y)-box 8SRY-box 8