ST7 antisense RNA 1 (non-protein coding) (ST7-AS1)

ST7 antisense RNA 1 (ST7-AS1) is a long non-coding RNA (lncRNA) transcribed antisense to the tumor suppressor gene ST7, located at chromosome 7q31.2[1][2]. It does not encode a protein but is increasingly recognized for its regulatory roles in gene expression. ST7-AS1 expression is significantly downregulated in certain cancers, notably breast cancer, where its low levels are associated with higher grade, advanced tumor stage, unfavorable clinicopathologic features, and poor prognosis[1][2]. Functionally, ST7-AS1 is implicated in tumor suppression by modulating key biological processes such as cell cycle, apoptosis, DNA repair, and various signaling pathways including JAK/STAT and Wnt/beta-catenin[1][2][4]. Additionally, its expression correlates with distinct patterns of immune cell infiltration in the tumor microenvironment[2]. Although it is not considered a direct therapeutic target (such as a receptor, enzyme, or transporter), ST7-AS1 may serve as a novel biomarker for cancer diagnosis and prognosis, and potentially as a molecular target for future RNA-based or antisense therapies[1][2][4]. At present, there are no known drugs or direct pharmacological modulators targeting ST7-AS1, and no major safety concerns have been identified for this non-coding RNA.

Other names

ST7AS1ST7 overlapping transcript antisense 1ST7OT1ST7 antisense RNA 1 (non-protein coding)ST7 overlapping transcript 1 (antisense non-coding RNA)ST7 overlapping transcript 1 (non-protein coding)