Stabilin-1 receptor (STAB1)

Stabilin-1 (STAB1) is a large, type I transmembrane scavenger receptor highly expressed on sinusoidal endothelial cells of the liver, spleen, lymph nodes, and on alternatively activated (M2-like) tissue macrophages. Its extracellular region features fasciclin, epidermal growth factor (EGF)-like, and laminin-type EGF-like domains, plus a hyaluronan-binding Link module. Stabilin-1 mediates endocytosis and clearance of modified lipoproteins (including oxidized and acetylated LDL), advanced glycosylation end products, Gram-positive and Gram-negative bacteria, extracellular matrix proteins like SPARC, placental lactogen, and apoptotic cells. Beyond its homeostatic scavenger role, Stabilin-1 modulates immune trafficking, leukocyte adhesion, regulatory T cell recruitment, and shapes anti-inflammatory or immunosuppressive responses, particularly in cancer and tissue injury settings. In liver and other tissues, it controls fibrosis resolution, modulates cytokine and chemokine signaling (notably suppressing profibrogenic CCL3 in macrophages), and regulates local immune homeostasis. Increased expression is observed in chronic inflammation, fibrosis, and tumor microenvironments. It is under active investigation as a therapeutic target for immune oncology and chronic inflammatory diseases.

Other names

FEEL-1CLEVER-1KIAA0246MS-1 antigenFELE-1FEX1SCARH2common lymphatic endothelial and vascular endothelial receptor-1fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor-1

Antibody-mediated blockade modulates immune cell trafficking, enhances antitumor immunity by reprogramming macrophages, reduces tumor-associated immune suppression