Stabilin-2 (STAB2)

Stabilin-2 (STAB2) is a large transmembrane scavenger receptor primarily expressed on sinusoidal endothelial cells of the liver, spleen, bone marrow, and lymph node, as well as selected tissues such as the heart and kidney[1][2][5][6]. It features seven fasciclin, 15 epidermal growth factor (EGF)-like, and two laminin-type EGF-like domains, plus a C-type lectin-like Link domain that binds hyaluronan and other glycosaminoglycans[1][2][3]. Its canonical function is the systemic clearance of hyaluronan from circulation and tissues, where it also mediates the uptake of other extracellular matrix molecules, advanced glycation end products, lipoproteins, and bacteria[1][2][3][7][8]. Stabilin-2 enables phagocytosis of apoptotic or necrotic cells by binding exposed phosphatidylserine, contributing to immune homeostasis and anti-inflammatory signaling[3]. Genetic deficiency or inhibition leads to increased circulating hyaluronan and impaired clearance, which can result in glomerular fibrosis and contribute to the pathogenesis of several diseases, including liver and kidney disorders, and cancer[2][4][5][9].

Other names

Hyaluronan receptor for endocytosisHAREFEEL2FELLFEEL-2SCARH1Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2Hepatic hyaluronan clearance receptor190 kDa form stabilin-2DKFZP434E0321FAS1 EGF-like and X-link domain-containing adhesion molecule 2CD44-like precursor FELL

Ligand binding and endocytosis (scavenging hyaluronan, heparin, chondroitin sulfates, LDL, advanced glycation end-products, bacteria); Intracellular signaling via ERK1/2 and NF-κB pathways upon ligand uptake[3]; Triggering anti-inflammatory responses, e.g. through IL-10 or TGF-β production during phagocytosis of apoptotic cells[3]