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Target intelligence / Profile preview
Stabilizer of axonemal microtubules 1 (SAXO1)
- Target
- SAXO1
- Molecular classification
- Microtubule-associated protein, Other
01
Overview
Stabilizer of axonemal microtubules 1 (SAXO1) is a microtubule-associated protein that specifically localizes to centrioles and cilia, where it stabilizes microtubules and plays a key role in the regulation of cilium length and function[1][2][6]. SAXO1 binds to microtubules via its Mn modules and is critical for cilium biogenesis and proper axoneme organization[1][2][6]. Although similar in function to MAP6 proteins, SAXO1 is specific for axonemal and centriolar structures and is not widely implicated as a therapeutic drug target[1][5]. No known drugs, associated disease roles, or biomarker/safety information are currently described for this protein[5][6].
- Other names
- C9orf138FAM154AMGC351824930500O09Rikfamily with sequence similarity 154 member Aprotein FAM154A
02
Biological functions
Microtubule stabilizationRegulation of cilium lengthCilium assemblyCytoskeletal organization
03
Disease associations
Other
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