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Stabilizer of axonemal microtubules 5 (SAXO5)

Target: SAXO5
Molecular classification: Other (microtubule-associated protein family)

Overview

Stabilizer of axonemal microtubules 5 (SAXO5) is a protein-coding gene whose product is part of a family previously known as DUF4601, associated with the stabilization of microtubules in axonemal structures—key for ciliary and flagellar function. SAXO5 is known by several aliases, including C19orf45 and TEX45, and is linked to disorders such as neonatal respiratory failure and microcephalic osteodysplastic primordial dwarfism, Type II. SAXO5 does not belong to classical druggable target families like receptors or enzymes, and no direct interacting drugs or biomarkers are described in the literature.

Other names: C19orf45TEX45testis-expressed protein 45FLJ35784uncharacterized protein C19orf45

Biological functions

Axonemal microtubule stabilization

Disease associations

Neonatal respiratory failureMicrocephalic osteodysplastic primordial dwarfism, Type II

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