STAG3 cohesin complex component like 1 (STAG3L1)

STAG3L1 is defined in databases as a pseudogene that is homologous to STAG3, a key component of the cohesin complex integral for sister chromatid cohesion in mitosis and meiosis[1][6]. While the cohesin complex—and specifically proteins like STAG3, STAG1, and STAG2—are essential for chromosome segregation, genome stability, and are implicated in various diseases including cancer and developmental disorders[3][4][5], STAG3L1 lacks evidence for encoding a functional protein and is not considered a validated molecular target or receptor[1][6][8]. STAG3, and not STAG3L1, plays established roles in chromosome segregation, meiosis, and has disease relevance[4][8]. The STAG proteins (STAG1, STAG2, STAG3) are core cohesin components, participating in chromatin organization and regulation, but STAG3L1 is annotated as a pseudogene and there is no evidence of it being translated or acting as a therapeutic target[1][6].

Other names

Putative STAG3-like protein 1STAG3L1PDKFZP434A0131Stromal antigen 3-like protein 1STAG3L2STAG3L3