STAG3 cohesin complex component like 2 (STAG3L2)

STAG3 cohesin complex component like 2 (STAG3L2) is a human pseudogene found on chromosome 7. It is named for its sequence similarity to STAG3, a protein involved in the cohesin complex critical for meiotic chromosome pairing, but unlike STAG3, STAG3L2 does not encode a functional protein. Pseudogenes like STAG3L2 typically arise through gene duplication or retrotransposition events and lose their protein-coding ability due to accumulated mutations. Diseases associated with the STAG3L2 locus include Williams-Beuren syndrome, but this association is through genomic position and not established gene function. Key insights: STAG3L2 is not a protein-coding gene; it is considered a pseudogene. There is no evidence supporting it as a therapeutic target or involved in cellular processes as a functional entity. No drugs, mechanisms, or biomarker roles are described, and there are no disease or safety concerns relevant to a functioning protein. The gene is listed in databases with aliases and connections to the STAG3 functional gene due to sequence similarity.

Other names

Putative STAG3-like protein 2STAG3L2MGC131759STAG3L2PStromal antigen 3-like protein 2