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Target intelligence / Profile preview
Stanniocalcin-1
- Molecular classification
- Secreted glycoprotein hormone, SUMO E3 ubiquitin ligase
01
Overview
Stanniocalcin-1 (STC1) is a secreted, homodimeric glycoprotein hormone that participates in a wide range of physiological and pathological processes. It regulates renal/intestinal calcium and phosphate transport, promotes cell cycle progression, protects against hypoxic/ischemic damage, and is critical for transendothelial migration of inflammatory cells. STC1 expression is altered across several cancers and is implicated in implantation and lactation processes.
- Other names
- STC1
02
Mechanism of action
SUMO E3 ubiquitin ligase activity
03
Biological functions
Mineral homeostasisCell metabolismCell cycle regulationCytoprotectionEndothelial functionReproductionAngiogenesisApoptosis modulationOxidative phosphorylation regulationCalcium channel blocker
04
Disease associations
CancerPregnancy complications
05
Biomarkers
Biomarker for leukemic microenvironments
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