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Target intelligence / Profile preview
Thermonuclease (TNase)
- Target
- TNase
- Molecular classification
- Enzyme, Endonuclease, DNase, RNase
01
Overview
Thermonuclease is a heat-stable, calcium-dependent endonuclease primarily produced by Staphylococcus aureus. It catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond, yielding 3'-mononucleotides. As a secreted enzyme, thermonuclease functions extracellularly and contributes to virulence by degrading neutrophil extracellular traps (NETs) and regulating biofilm formation. Two main forms exist: secreted Nuc1 and cell-surface attached Nuc2, each playing distinct roles in S. aureus pathogenicity. Its enzymatic activity is utilized for rapid identification of S. aureus in clinical diagnostics.
- Other names
- Micrococcal nucleaseStaphylococcal nucleaseNuc1Nuc2EC 3.1.31.1
02
Mechanism of action
Hydrolyzes phosphodiester bonds in DNA and RNA
03
Biological functions
Hydrolysis of DNAHydrolysis of RNAImmune evasionBiofilm regulationVirulence
04
Disease associations
Infection
05
Safety considerations
Potential for non-specific degradation of nucleic acidsRole in bacterial pathogenesis
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