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Target intelligence / Profile preview
Staphylococcus alpha-hemolysin (Hla)
- Target
- Hla
- Molecular classification
- Pore-forming toxin, Virulence factor, Toxin
01
Overview
Staphylococcus alpha-hemolysin, also known as alpha-toxin or Hla, is a major cytotoxic protein secreted by Staphylococcus aureus. It forms a heptameric transmembrane pore in host cell membranes, leading to ion imbalance and cell death. It is an essential virulence factor contributing to tissue destruction and immune evasion during infections.
- Other names
- Alpha-toxinhlyhla
02
Mechanism of action
Forms a heptameric transmembrane pore in host cell membranes, leading to ion imbalance and cell death.
03
Biological functions
Membrane disruptionCell lysisApoptosis inductionNecrosis inductionNLRP3 inflammasome activationImmune evasion
04
Disease associations
PneumoniaSkin/soft tissue infectionsSepsisSeptic arthritisBrain abscessesCorneal infectionsMRSA infections
05
Safety considerations
Tissue destructionInflammationImmune evasion
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