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Target intelligence / Profile preview
Staphylococcus aureus capsular polysaccharide serotype 8 (CP8)
- Target
- CP8
- Molecular classification
- Bacterial capsular polysaccharide, Polysaccharide
01
Overview
Staphylococcus aureus capsular polysaccharide serotype 8 (CP8) is a high-molecular-weight carbohydrate polymer that forms a protective capsule around certain S. aureus strains. This capsule is one of the two predominant serotypes (the other being serotype 5, CP5) found among clinical isolates of S. aureus. The presence of this capsule enhances bacterial virulence by impeding phagocytosis and promoting persistence in the host bloodstream. It consists of repeating trisaccharide units made up of three rare monosaccharides: N-acetyl d-mannosaminuronic acid (ManNAcA), N-acetyl l-fucosamine (l-FucNAc), and N-acetyl d-fucosamine (d-FucNAc).
02
Mechanism of action
Antibodies targeting CP8 can promote opsonization and enhance killing by immune cells when administered as antisera or induced via conjugate vaccines
03
Biological functions
Immune evasionProtection against phagocytosisVirulence factor
04
Disease associations
Invasive Staphylococcus aureus infections
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