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Target intelligence / Profile preview
Staphylococcus aureus Cell Membrane (N/A)
- Target
- N/A
- Molecular classification
- Lipid Bilayer, Membrane, Cell Membrane
01
Overview
The cell membrane of *Staphylococcus aureus* is a critical lipid bilayer separating the cytoplasm from the external environment, working with the peptidoglycan cell wall. It's composed primarily of phosphatidylglycerol (PG), lysyl-phosphatidylglycerol (Lys-PG), and cardiolipin (CL), with the ratio changing based on environmental conditions. Lys-PG confers resistance to cationic antimicrobial peptides (CAMPs). The membrane contains functional microdomains (FMMs) organized by flotillin A (FloA), which coordinate cell wall biosynthesis, beta-lactam antibiotic resistance, and secretion. Essential proteins for lipid metabolism, like PlsY and CdsA, exhibit large-scale patterns dependent on MreD. The membrane plays a key role in virulence and antibiotic resistance mechanisms.
- Other names
- S. aureus Cell MembraneStaphylococcus aureus Plasma MembraneS. aureus Plasma Membrane
02
Mechanism of action
N/A
03
Biological functions
Barrier functionTransportSignal transductionMaintenance of cell integrityAntimicrobial resistanceCell wall biosynthesisSecretion
04
Disease associations
InfectionAntibiotic ResistanceVirulence
05
Safety considerations
Development of resistanceDisruption of membrane integrity can lead to cell death
06
Interacting drugs
Cationic antimicrobial peptides (CAMPs)
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